The science behind Genome Health Analysis has been subjected to rigorous
scrutiny from scientists internationally, as demonstrated by the number
of published articles about the subject. The researchers who developed
Genome Health Analysis have had articles published in 17 leading international
scientific journals. To be published in such journals, the papers must
pass a process called “peer review”, meaning leading scientists
review the submitted work to check for authenticity and credibility.
The articles have also been cited widely by scientists, attesting to
the cutting-edge nature of Genome Health Analysis.
Selection of Key Publications
- Fenech, M. and Morley, A.A. (1985) Measurement of micronuclei
in human lymphocytes. Mutation Res. 148, 29-36. (cited 808 times)
- Fenech M and Morley (1986) Cytokinesis-block micronucleus method
in human-lymphocytes - effect of invivo aging and low-dose x-irradiation.
Mutation Res 161 (2): 193-198.(cited: 231 times).
- Fenech M a nd Morley (1989) Kinetochore detection in micronuclei
- an alternative method for measuring chromosome loss. Mutagenesis
4 (2): 98-104. (cited 125 times)
- Fenech, M., Denham, J., Francis W. and Morley, A.A. (1990) "The
cytokinesis-block micronucleus assay: biological dosimetry in cancer
patients following in vivo fractionated exposure to ionising radiation".
International Journal of Radiation Biology, 57(2), 373-383. (cited
- Fenech M (1993) the cytokinesis-block micronucleus technique -
a detailed description of the method and its application to genotoxicity
studies in human-populations. Mutation Res 285 (1): 35-44. (cited 367
- Fenech M., C. Aitken and J. Rinaldi (1998) Folate, vitamin B12,
homocysteine status and DNA damage in young Australian adults. Carcinogenesis
(accelerated paper) 19(7): 1163-1171. (cited 99 times)
- Fenech M (2000) The in vitro micronucleus technique. Mutation Res
455 (1-2): 81-95. (cited 114 times)
- Fenech M, Crott J, Turner J and Brown S (1999) Necrosis, apoptosis,
cytostasis and DNA damage in human lymphocytes measured simultaneously
within the cytokinesis-block micronucleus assay: description of the
method and results for hydrogen peroxide Mutagenesis 14 (6): 605-612
NOV 1999 (cited 55 times)
- Crott JW, Mashiyama ST, Ames BN, Fenech M (2001) MTHFR C677T polymorphism
does not alter folic acid deficiency-induced uracil incorporation into
primary lymphocyte DNA in vitro. (accelerated paper) Carcinogenesis
22(7): 1019-1025. (cited 38 times)
- Crott JW and Fenech M (2001) The effect of folic acid deficiency
and MTHFR C677T polymorphism on chromosome damage in human lymphocytes
in vitro. Cancer Epidemiology Biomarkers and Prevention 10:1089-1096.
(cited 30 times).
- Fenech M (2001)The role of folic acid and Vitamin B12 in genomic
stability of human cells. Mutation Res. 475 (1-2): 57-67 (cited 69
- Manual in Biodosimetry, TRS-405, International Atomic Energy Agency,
2001. (contributed section on the cytokinesis-block micronucleus assay).
- Fenech M. (2001) Recommended dietary allowances for genomic stability.
Mutation Res. 480-481: 51-54. (cited 16 times)
- Fenech M. (2002) Genomic Stability: a new paradigm for recommended
dietary allowances (RDAs). Food and Chemical Toxicology 40: 1113-1117.
(cited 13 times)
- Michiyo Kimura, Keizo Umegaki, Mitsuru Higuchi, Philip Thomas
and Michael Fenech (2004) MTHFR C677T polymorphism, folic acid and
riboflavin are important determinants of genome stability in cultured
human lymphocytes. J. Nutrition 134(1):48-56. (cited 11 times).
- Fenech M, Baghurst P , Luderer W, Turner J, Record S, Ceppi M,
Bonassi S (2005) Low intake of calcium, folate, nicotinic acid, vitamin
E, retinol, ß-carotene
and high intake of pantothenic acid, biotin and riboflavin are significantly
associated with increased genome instability – results from a dietary
intake and micronucleus index survey in South Australia. Carcinogenesis
26(5):991-9. Epub 2005 Feb 10. (cited 3 times)
- Fenech M. (2005)The Genome Health Clinic and Genome Health Nutrigenomics
concepts: diagnosis and nutritional treatment of genome and epigenome
damage on an individual basis. Mutagenesis. 2005 Jul;20(4):255-69. Epub
2005 Jun 14. Review. (cited 4 times)
- Fenech M et al (2006) The Cytokinesis-block Micronucleus and Cytome
Assay. Nature Protocols (invited paper in preparation)