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Research & Science

The science behind Genome Health Analysis has been subjected to rigorous scrutiny from scientists internationally, as demonstrated by the number of published articles about the subject. The researchers who developed Genome Health Analysis have had articles published in 17 leading international scientific journals. To be published in such journals, the papers must pass a process called “peer review”, meaning leading scientists review the submitted work to check for authenticity and credibility. The articles have also been cited widely by scientists, attesting to the cutting-edge nature of Genome Health Analysis.
 

Selection of Key Publications

  1. Fenech, M. and Morley, A.A. (1985) Measurement of micronuclei in human lymphocytes. Mutation Res. 148, 29-36. (cited 808 times)
  2. Fenech M and Morley (1986) Cytokinesis-block micronucleus method in human-lymphocytes - effect of invivo aging and low-dose x-irradiation. Mutation Res 161 (2): 193-198.(cited: 231 times).
  3. Fenech M a nd Morley (1989) Kinetochore detection in micronuclei - an alternative method for measuring chromosome loss. Mutagenesis 4 (2): 98-104. (cited 125 times)
  4. Fenech, M., Denham, J., Francis W. and Morley, A.A. (1990) "The cytokinesis-block micronucleus assay: biological dosimetry in cancer patients following in vivo fractionated exposure to ionising radiation". International Journal of Radiation Biology, 57(2), 373-383. (cited 76 times)
  5. Fenech M (1993) the cytokinesis-block micronucleus technique - a detailed description of the method and its application to genotoxicity studies in human-populations. Mutation Res 285 (1): 35-44. (cited 367 times)
  6. Fenech M., C. Aitken and J. Rinaldi (1998) Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis (accelerated paper) 19(7): 1163-1171. (cited 99 times)
  7. Fenech M (2000) The in vitro micronucleus technique. Mutation Res 455 (1-2): 81-95. (cited 114 times)
  8. Fenech M, Crott J, Turner J and Brown S (1999) Necrosis, apoptosis, cytostasis and DNA damage in human lymphocytes measured simultaneously within the cytokinesis-block micronucleus assay: description of the method and results for hydrogen peroxide Mutagenesis 14 (6): 605-612 NOV 1999 (cited 55 times)
  9. Crott JW, Mashiyama ST, Ames BN, Fenech M (2001) MTHFR C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary lymphocyte DNA in vitro. (accelerated paper) Carcinogenesis 22(7): 1019-1025. (cited 38 times)
  10. Crott JW and Fenech M (2001) The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. Cancer Epidemiology Biomarkers and Prevention 10:1089-1096. (cited 30 times).
  11. Fenech M (2001)The role of folic acid and Vitamin B12 in genomic stability of human cells. Mutation Res. 475 (1-2): 57-67 (cited 69 times)
  12. Manual in Biodosimetry, TRS-405, International Atomic Energy Agency, 2001. (contributed section on the cytokinesis-block micronucleus assay).
  13. Fenech M. (2001) Recommended dietary allowances for genomic stability. Mutation Res. 480-481: 51-54. (cited 16 times)
  14. Fenech M. (2002) Genomic Stability: a new paradigm for recommended dietary allowances (RDAs). Food and Chemical Toxicology 40: 1113-1117. (cited 13 times)
  15. Michiyo Kimura, Keizo Umegaki, Mitsuru Higuchi, Philip Thomas and Michael Fenech (2004) MTHFR C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes. J. Nutrition 134(1):48-56. (cited 11 times).
  16. Fenech M, Baghurst P , Luderer W, Turner J, Record S, Ceppi M, Bonassi S (2005) Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, ß-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability – results from a dietary intake and micronucleus index survey in South Australia. Carcinogenesis 26(5):991-9. Epub 2005 Feb 10. (cited 3 times)
  17. Fenech M. (2005)The Genome Health Clinic and Genome Health Nutrigenomics concepts: diagnosis and nutritional treatment of genome and epigenome damage on an individual basis. Mutagenesis. 2005 Jul;20(4):255-69. Epub 2005 Jun 14. Review. (cited 4 times)
  18. Fenech M et al (2006) The Cytokinesis-block Micronucleus and Cytome Assay. Nature Protocols (invited paper in preparation)